Thymine DNA glycosylase (TDG) Mouse Monoclonal Antibody [Clone ID: LBI3C11]
Product Specifications
Background
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
Synonyms
HTDG
Gene Name
Homo sapiens thymine DNA glycosylase (TDG), transcript variant 1, mRNA.
Gene ID
6996
UniProt
Q13569
Conjugation
Unconjugated
Related Pathways
Base excision repair
Field of Research
Base excision repair
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TDG
Overview
Carrier-free (BSA/glycerol-free) TDG mouse monoclonal antibody, clone LBI3C11
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6996
Uniprot URL
https://www.uniprot.org/uniprot/Q13569
Curated Selection
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