ERCC8 Mouse Monoclonal Antibody [Clone ID: LBI1G2]
Product Specifications
Background
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Synonyms
CKN1; CSA; UVSS2
Gene Name
Homo sapiens ERCC excision repair 8, CSA ubiquitin ligase complex subunit (ERCC8), transcript variant 3, mRNA.
Gene ID
1161
UniProt
Q13216
Conjugation
Unconjugated
Related Pathways
Nucleotide excision repair, Ubiquitin mediated proteolysis
Field of Research
Nucleotide excision repair, Ubiquitin mediated proteolysis
Dilution
WB 1:500, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Transcription Factors
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ERCC8
Overview
Carrier-free (BSA/glycerol-free) ERCC8 mouse monoclonal antibody, clone LBI1G2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1161
Uniprot URL
https://www.uniprot.org/uniprot/Q13216
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