ERCC8 Mouse Monoclonal Antibody [Clone ID: LBI1G2]

Product Specifications

Background

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Overview

Carrier-free (BSA/glycerol-free) ERCC8 mouse monoclonal antibody, clone LBI1G2

Synonyms

CKN1; CSA; UVSS2

Gene Name

Homo sapiens ERCC excision repair 8, CSA ubiquitin ligase complex subunit (ERCC8), transcript variant 3, mRNA.

Gene ID

1161

UniProt

Q13216

Conjugation

Unconjugated

Related Pathways

Nucleotide excision repair, Ubiquitin mediated proteolysis

Field of Research

Nucleotide excision repair, Ubiquitin mediated proteolysis

Dilution

WB 1:500, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Transcription Factors

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.