Cardiac Troponin T (TNNT2) Mouse Monoclonal Antibody [Clone ID: LBI3C6]
Product Specifications
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) . [provided by RefSeq, Jul
Overview
Carrier-free (BSA/glycerol-free) TNNT2 mouse monoclonal antibody, clone LBI3C6
Synonyms
CMD1D; CMH2; CMPD2; cTnT; LVNC6; RCM3; TnTC
Gene Name
Homo sapiens troponin T2, cardiac type (TNNT2), transcript variant 1, mRNA.
Gene ID
7139
UniProt
P45379
Conjugation
Unconjugated
Related Pathways
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TNNT2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7139
Uniprot URL
https://www.uniprot.org/uniprot/P45379
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