Cardiac Troponin I (TNNI3) Mouse Monoclonal Antibody [Clone ID: LBI3H9]
Product Specifications
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) . [provided by RefSeq, Jul
Overview
Carrier-free (glycerol/BSA-free) TNNI3 mouse monoclonal antibody, clone LBI3H9
Synonyms
CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
Gene Name
Homo sapiens troponin I3, cardiac type (TNNI3), mRNA.
Gene ID
7137
UniProt
P19429
Conjugation
Unconjugated
Related Pathways
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TNNI3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7137
Uniprot URL
https://www.uniprot.org/uniprot/P19429
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