DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: LBI11B12]

Product Specifications

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) TNFRSF10A mouse monoclonal antibody, clone LBI11B12

Synonyms

APO2; CD261; DR4; TRAILR-1; TRAILR1

Gene Name

Homo sapiens TNF receptor superfamily member 10a (TNFRSF10A), mRNA.

Gene ID

8797

UniProt

O00220

Conjugation

Unconjugated

Related Pathways

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Field of Research

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Dilution

WB 1:2000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.