RNF20 Mouse Monoclonal Antibody [Clone ID: LBI2B9]
Product Specifications
Background
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS) . [provided by RefSeq, Feb 2012]
Synonyms
BRE1; BRE1A; hBRE1
Gene Name
Homo sapiens ring finger protein 20 (RNF20), mRNA.
Gene ID
56254
UniProt
Q5VTR2
Conjugation
Unconjugated
Dilution
WB 1:500, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RNF20
Overview
Carrier-free (BSA/glycerol-free) RNF20 mouse monoclonal antibody, clone LBI2B9
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=56254
Uniprot URL
https://www.uniprot.org/uniprot/Q5VTR2
Curated Selection
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