PDX1 Mouse Monoclonal Antibody [Clone ID: LBI4D8]

Product Specifications

Background

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4) . [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) PDX1 mouse monoclonal antibody, clone LBI4D8

Synonyms

GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1

Gene Name

Homo sapiens pancreatic and duodenal homeobox 1 (PDX1), mRNA.

Gene ID

3651

UniProt

P52945

Conjugation

Unconjugated

Related Pathways

Maturity onset diabetes of the young, Type II diabetes mellitus

Field of Research

Maturity onset diabetes of the young, Type II diabetes mellitus

Dilution

WB 1:2000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.