5 Lipoxygenase (ALOX5) Mouse Monoclonal Antibody [Clone ID: LBI3F1]

Product Specifications

Background

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5 (S) -hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5 (S) -trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4) . Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Overview

Carrier-free (BSA/glycerol-free) ALOX5 mouse monoclonal antibody, clone LBI3F1

Synonyms

5-LO; 5-LOX; 5LPG; LOG5

Gene Name

Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 1, mRNA.

Gene ID

240

UniProt

P09917

Conjugation

Unconjugated

Related Pathways

Arachidonic acid metabolism, Metabolic pathways

Field of Research

Arachidonic acid metabolism, Metabolic pathways

Dilution

WB 1:2000, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.