PHGDH Mouse Monoclonal Antibody [Clone ID: LBI9C2]
Product Specifications
Background
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
Synonyms
3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA
Gene Name
Homo sapiens phosphoglycerate dehydrogenase (PHGDH), mRNA.
Gene ID
26227
UniProt
O43175
Conjugation
Unconjugated
Related Pathways
Glycine, serine and threonine metabolism, Metabolic pathways
Field of Research
Glycine, serine and threonine metabolism, Metabolic pathways
Dilution
WB 1:500, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Stem cell - Pluripotency
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PHGDH
Overview
Carrier-free (BSA/glycerol-free) PHGDH mouse monoclonal antibody, clone LBI9C2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=26227
Uniprot URL
https://www.uniprot.org/uniprot/O43175
Curated Selection
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