UBE2D2 Mouse Monoclonal Antibody [Clone ID: LBI1D6]
Product Specifications
Background
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub) -proteasome system (UPS) . An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5) . Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Synonyms
E2 (17) KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Gene Name
Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA.
Gene ID
7322
UniProt
P62837
Conjugation
Unconjugated
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Dilution
WB 1:2000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
UBE2D2
Overview
Carrier-free (BSA/glycerol-free) UBE2D2 mouse monoclonal antibody, clone LBI1D6
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7322
Uniprot URL
https://www.uniprot.org/uniprot/P62837
Curated Selection
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