TNFRSF18 Mouse Monoclonal Antibody [Clone ID: LBI9G8]
Product Specifications
Background
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb
Synonyms
AITR; CD357; GITR; GITR-D
Gene Name
Homo sapiens TNF receptor superfamily member 18 (TNFRSF18), transcript variant 1, mRNA.
Gene ID
8784
UniProt
Q9Y5U5
Conjugation
Unconjugated
Related Pathways
Cytokine-cytokine receptor interaction
Field of Research
Cytokine-cytokine receptor interaction
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Secreted Protein, Transmembrane
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TNFRSF18
Overview
Carrier-free (BSA/glycerol-free) TNFRSF18 mouse monoclonal antibody, clone LBI9G8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8784
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y5U5
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