RET Mouse Monoclonal Antibody [Clone ID: LBI4H3]

Product Specifications

Background

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) RET mouse monoclonal antibody, clone LBI4H3

Synonyms

CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51

Gene Name

Homo sapiens ret proto-oncogene (RET), transcript variant 2, mRNA.

Gene ID

5979

UniProt

P07949

Conjugation

Unconjugated

Related Pathways

Endocytosis, Pathways in cancer, Thyroid cancer

Field of Research

Endocytosis, Pathways in cancer, Thyroid cancer

Dilution

WB 1:500, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Protein Kinase, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.