Rb (RB1) Mouse Monoclonal Antibody [Clone ID: LBI3F11]
Product Specifications
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Overview
Carrier-free (BSA/glycerol-free) RB1 mouse monoclonal antibody, clone LBI3F11
Synonyms
OSRC; p105-Rb; pp110; PPP1R130; pRb; RB
Gene Name
Homo sapiens RB transcriptional corepressor 1 (RB1), mRNA.
Gene ID
5925
UniProt
P06400
Conjugation
Unconjugated
Related Pathways
Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer
Field of Research
Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer
Dilution
WB 1:200, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Transcription Factors
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RB1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5925
Uniprot URL
https://www.uniprot.org/uniprot/P06400
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