Apolipoprotein E (APOE) Mouse Monoclonal Antibody [Clone ID: LBI2A4]

Product Specifications

Background

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) APOE mouse monoclonal antibody, clone LBI2A4

Synonyms

AD2; APO-E; LDLCQ5; LPG

Gene Name

Homo sapiens apolipoprotein E (APOE), transcript variant 2, mRNA.

Gene ID

348

UniProt

P02649

Conjugation

Unconjugated

Related Pathways

Alzheimer's disease

Field of Research

Alzheimer's disease

Dilution

WB 1:500, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.