Cardiac Troponin I (TNNC1) Mouse Monoclonal Antibody [Clone ID: LBI8F8]
Product Specifications
Background
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Synonyms
CMD1Z; CMH13; TN-C; TNC; TNNC
Gene Name
Homo sapiens troponin C1, slow skeletal and cardiac type (TNNC1), mRNA.
Gene ID
7134
UniProt
P63316
Conjugation
Unconjugated
Related Pathways
Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TNNC1
Overview
Carrier-free (BSA/glycerol-free) TNNC1 mouse monoclonal antibody, clone LBI8F8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7134
Uniprot URL
https://www.uniprot.org/uniprot/P63316
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