PRAK (MAPKAPK5) Mouse Monoclonal Antibody [Clone ID: LBI1D11]

Product Specifications

Background

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov

Overview

Carrier-free (glycerol/BSA-free) MAPKAPK5 mouse monoclonal antibody, clone LBI1D11

Synonyms

MAPKAP-K5; MK-5; MK5; PRAK

Gene Name

Homo sapiens MAPK activated protein kinase 5 (MAPKAPK5), transcript variant 1, mRNA.

Gene ID

8550

UniProt

Q8IW41

Conjugation

Unconjugated

Related Pathways

MAPK signaling pathway

Field of Research

MAPK signaling pathway

Dilution

WB 1:2000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Protein Kinase

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.