PRAK (MAPKAPK5) Mouse Monoclonal Antibody [Clone ID: LBI1H3]
Product Specifications
Background
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov
Synonyms
MAPKAP-K5; MK-5; MK5; PRAK
Gene Name
Homo sapiens MAPK activated protein kinase 5 (MAPKAPK5), transcript variant 1, mRNA.
Gene ID
8550
UniProt
Q8IW41
Conjugation
Unconjugated
Related Pathways
MAPK signaling pathway
Field of Research
MAPK signaling pathway
Dilution
WB 1:2000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Protein Kinase
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MAPKAPK5
Overview
Carrier-free (BSA/glycerol-free) MAPKAPK5 mouse monoclonal antibody, clone LBI1H3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8550
Uniprot URL
https://www.uniprot.org/uniprot/Q8IW41
Curated Selection
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