MSH6 Mouse Monoclonal Antibody [Clone ID: UMLBI258]
Product Specifications
Background
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Synonyms
GTBP; GTMBP; HNPCC5; HSAP; MMRCS3; p160
Gene Name
Homo sapiens mutS homolog 6 (MSH6), transcript variant 1, mRNA.
Gene ID
2956
UniProt
P52701
Conjugation
Unconjugated
Related Pathways
Colorectal cancer, Mismatch repair, Pathways in cancer
Field of Research
Colorectal cancer, Mismatch repair, Pathways in cancer
Concentration
0.5~1.0 mg/ml (Lot Dependent)
Dilution
IHC 1:50
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Stem cell - Pluripotency
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MSH6
Overview
MSH6 mouse monoclonal antibody, clone UMLBI258
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2956
Uniprot URL
https://www.uniprot.org/uniprot/P52701
Curated Selection
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