MLH1 Mouse Monoclonal Antibody [Clone ID: UMLBI191]

Product Specifications

Background

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq, Nov 2009]

Overview

MLH1 mouse monoclonal antibody, clone UMLBI191

Synonyms

COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1

Gene Name

Homo sapiens mutL homolog 1 (MLH1), transcript variant 1, mRNA.

Gene ID

4292

UniProt

P40692

Conjugation

Unconjugated

Related Pathways

Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer

Field of Research

Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer

Concentration

0.5~1.0 mg/ml (Lot Dependent)

Dilution

IHC 1:200

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.