GLI1 Mouse Monoclonal Antibody [Clone ID: UMLBI170]

Product Specifications

Background

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Overview

GLI1 mouse monoclonal antibody, clone UMLBI170

Synonyms

GLI

Gene Name

Homo sapiens GLI family zinc finger 1 (GLI1), transcript variant 1, mRNA.

Gene ID

2735

UniProt

P08151

Conjugation

Unconjugated

Related Pathways

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Field of Research

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Concentration

0.5~1.0 mg/ml (Lot Dependent)

Dilution

IHC 1:100~200

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.