PARN Mouse Monoclonal Antibody [Clone ID: UMLBI143]

Product Specifications

Background

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly (A) as the substrate, hence, efficiently degrades poly (A) tails of mRNAs. Exonucleolytic degradation of the poly (A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Overview

PARN mouse monoclonal antibody, clone UMLBI143

Synonyms

DAN

Gene Name

Homo sapiens poly (A) -specific ribonuclease (PARN), transcript variant 1, mRNA.

Gene ID

5073

UniProt

O95453

Conjugation

Unconjugated

Related Pathways

RNA degradation

Field of Research

RNA degradation

Concentration

0.5~1.0 mg/ml (Lot Dependent)

Dilution

WB 1:2000, IHC 1:100~200

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Transcription Factors

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.