PARN Mouse Monoclonal Antibody [Clone ID: UMLBI143]
Product Specifications
Background
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly (A) as the substrate, hence, efficiently degrades poly (A) tails of mRNAs. Exonucleolytic degradation of the poly (A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Synonyms
DAN
Gene Name
Homo sapiens poly (A) -specific ribonuclease (PARN), transcript variant 1, mRNA.
Gene ID
5073
UniProt
O95453
Conjugation
Unconjugated
Related Pathways
RNA degradation
Field of Research
RNA degradation
Concentration
0.5~1.0 mg/ml (Lot Dependent)
Dilution
WB 1:2000, IHC 1:100~200
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Transcription Factors
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PARN
Overview
PARN mouse monoclonal antibody, clone UMLBI143
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5073
Uniprot URL
https://www.uniprot.org/uniprot/O95453
Curated Selection
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