DOCK2 Mouse Monoclonal Antibody [Clone ID: UMLBI142]
Product Specifications
Background
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Synonyms
FLJ46592; IMD40; KIAA0209
Gene Name
Homo sapiens dedicator of cytokinesis 2 (DOCK2), transcript variant 1, mRNA.
Gene ID
1794
UniProt
Q92608
Conjugation
Unconjugated
Related Pathways
Chemokine signaling pathway, Fc gamma R-mediated phagocytosis
Field of Research
Chemokine signaling pathway, Fc gamma R-mediated phagocytosis
Concentration
0.5~1.0 mg/ml (Lot Dependent)
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
DOCK2
Overview
DOCK2 mouse monoclonal antibody, clone UMLBI142
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1794
Uniprot URL
https://www.uniprot.org/uniprot/Q92608
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