DOCK2 Mouse Monoclonal Antibody [Clone ID: UMLBI142]

Product Specifications

Background

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]

Overview

DOCK2 mouse monoclonal antibody, clone UMLBI142

Synonyms

FLJ46592; IMD40; KIAA0209

Gene Name

Homo sapiens dedicator of cytokinesis 2 (DOCK2), transcript variant 1, mRNA.

Gene ID

1794

UniProt

Q92608

Conjugation

Unconjugated

Related Pathways

Chemokine signaling pathway, Fc gamma R-mediated phagocytosis

Field of Research

Chemokine signaling pathway, Fc gamma R-mediated phagocytosis

Concentration

0.5~1.0 mg/ml (Lot Dependent)

Dilution

WB 1:2000, IHC 1:150

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.