ERCC1 Mouse Monoclonal Antibody [Clone ID: 2E12]
Product Specifications
Background
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq]
Synonyms
COFS4; RAD10; UV20
Gene Name
Homo sapiens ERCC excision repair 1, endonuclease non-catalytic subunit (ERCC1), transcript variant 2, mRNA.
Gene ID
2067
UniProt
P07992
Conjugation
Unconjugated
Related Pathways
Nucleotide excision repair
Field of Research
Nucleotide excision repair
Concentration
0.5~1.0 mg/ml (Lot Dependent)
Dilution
WB 1:500~1000, IHC 1:150, IF 1:100, FLOW 1:100
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ERCC1
Overview
ERCC1 mouse monoclonal antibody, clone 2E12
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2067
Uniprot URL
https://www.uniprot.org/uniprot/P07992
Curated Selection
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