Neurofilament (NEFL) Mouse Monoclonal Antibody [Clone ID: LBI2D1]

Product Specifications

Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Overview

NEFL mouse monoclonal antibody, clone LBI2D1

Synonyms

CMT1F; CMT2E; CMTDIG; NF-L; NF68; NFL; PPP1R110

Gene Name

Neurofilament, light polypeptide

Gene ID

4747

UniProt

P07196

Conjugation

Unconjugated

Related Pathways

Amyotrophic lateral sclerosis (ALS)

Field of Research

Amyotrophic lateral sclerosis (ALS)

Concentration

1 mg/ml

Dilution

ELISA 1:5000-10000

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, ES Cell Differentiation/IPS

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.