CTLA4 Mouse Monoclonal Antibody [Clone ID: LBI8B5]

Product Specifications

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Overview

CTLA4 mouse monoclonal antibody, clone LBI8B5

Synonyms

ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12

Gene Name

Cytotoxic T-lymphocyte associated protein 4

Gene ID

1493

UniProt

P16410

Conjugation

Unconjugated

Related Pathways

Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Field of Research

Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Concentration

1 mg/ml

Dilution

FLOW 1:400

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Transmembrane

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.