CTLA4 Mouse Monoclonal Antibody [Clone ID: LBI8B5]
Product Specifications
Background
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Overview
CTLA4 mouse monoclonal antibody, clone LBI8B5
Synonyms
ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Gene Name
Cytotoxic T-lymphocyte associated protein 4
Gene ID
1493
UniProt
P16410
Conjugation
Unconjugated
Related Pathways
Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway
Field of Research
Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway
Concentration
1 mg/ml
Dilution
FLOW 1:400
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CTLA4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1493
Uniprot URL
https://www.uniprot.org/uniprot/P16410
Curated Selection
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