AMPK beta 1 (PRKAB1) Mouse Monoclonal Antibody [Clone ID: LBI3B11]
Product Specifications
Background
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) . [UniProtKB/Swiss-Prot Function]
Synonyms
AMPK; HAMPKb
Gene Name
Protein kinase AMP-activated non-catalytic subunit beta 1
Gene ID
5564
UniProt
Q9Y478
Conjugation
Unconjugated
Related Pathways
Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway
Field of Research
Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:500
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PRKAB1
Overview
PRKAB1 mouse monoclonal antibody, clone LBI3B11
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5564
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y478
Curated Selection
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