Cathepsin L (CTSL) Mouse Monoclonal Antibody [Clone ID: LBI5C8]
Product Specifications
Background
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Synonyms
CATL; CTSL1; MEP
Gene Name
Cathepsin L
Gene ID
1514
UniProt
P07711
Conjugation
Unconjugated
Related Pathways
Antigen processing and presentation, Lysosome
Field of Research
Antigen processing and presentation, Lysosome
Concentration
1 mg/ml
Dilution
WB 1:500, IHC 1:500
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protease
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CTSL
Overview
CTSL mouse monoclonal antibody, clone LBI5C8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1514
Uniprot URL
https://www.uniprot.org/uniprot/P07711
Curated Selection
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