NEDD4 Mouse Monoclonal Antibody [Clone ID: LBI6B2]

Product Specifications

Background

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

Overview

NEDD4 mouse monoclonal antibody, clone LBI6B2

Synonyms

NEDD4-1; RPF1

Gene Name

Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Gene ID

4734

UniProt

P46934

Conjugation

Unconjugated

Related Pathways

Endocytosis, Ubiquitin mediated proteolysis

Field of Research

Endocytosis, Ubiquitin mediated proteolysis

Concentration

1 mg/ml

Dilution

WB 1:500

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.