Beta Arrestin 1 (ARRB1) Mouse Monoclonal Antibody [Clone ID: LBI2B3]

Product Specifications

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].

Overview

ARRB1 mouse monoclonal antibody, clone LBI2B3

Synonyms

ARB1; ARR1

Gene Name

Arrestin beta 1

Gene ID

408

UniProt

P49407

Conjugation

Unconjugated

Related Pathways

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Field of Research

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.