Beta Arrestin 1 (ARRB1) Mouse Monoclonal Antibody [Clone ID: LBI2B3]
Product Specifications
Background
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].
Synonyms
ARB1; ARR1
Gene Name
Arrestin beta 1
Gene ID
408
UniProt
P49407
Conjugation
Unconjugated
Related Pathways
Chemokine signaling pathway, Endocytosis, MAPK signaling pathway
Field of Research
Chemokine signaling pathway, Endocytosis, MAPK signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ARRB1
Overview
ARRB1 mouse monoclonal antibody, clone LBI2B3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=408
Uniprot URL
https://www.uniprot.org/uniprot/P49407
Curated Selection
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