MASP2 Mouse Monoclonal Antibody [Clone ID: LBI7C4]
Product Specifications
Background
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Overview
MASP2 mouse monoclonal antibody, clone LBI7C4
Synonyms
MAP-2; MAP19; MASP-2; MASP1P1; sMAP
Gene Name
Mannan binding lectin serine peptidase 2
Gene ID
10747
UniProt
O00187
Conjugation
Unconjugated
Related Pathways
Complement and coagulation cascades
Field of Research
Complement and coagulation cascades
Concentration
1 mg/ml
Dilution
WB 1:500
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protease, Secreted Protein
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MASP2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=10747
Uniprot URL
https://www.uniprot.org/uniprot/O00187
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