Prothrombin (F2) Mouse Monoclonal Antibody [Clone ID: LBI5G10]
Product Specifications
Background
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Synonyms
PT; RPRGL2; THPH1
Gene Name
Coagulation factor II, thrombin
Gene ID
2147
UniProt
P00734
Conjugation
Unconjugated
Related Pathways
Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton
Field of Research
Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton
Concentration
1 mg/ml
Dilution
WB 1:500
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protease, Secreted Protein
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
F2
Overview
F2 mouse monoclonal antibody, clone LBI5G10
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2147
Uniprot URL
https://www.uniprot.org/uniprot/P00734
Curated Selection
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