DIP13B (APPL2) Mouse Monoclonal Antibody [Clone ID: LBI6G8]
Product Specifications
Background
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t (12;22) (q24.1; q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Synonyms
DIP13B
Gene Name
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Gene ID
55198
UniProt
Q8NEU8
Conjugation
Unconjugated
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
APPL2
Overview
APPL2 mouse monoclonal antibody, clone LBI6G8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=55198
Uniprot URL
https://www.uniprot.org/uniprot/Q8NEU8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
