Estradiol benzoate

Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice[1][2][3][4][5].

Product Specifications

CAS Number

[50-50-0]

Product Name Alternative

β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate

UNSPSC

12352005

Hazard Statement

H351, H360

Target

Bcl-2 Family; Estrogen Receptor/ERR; HBV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Estradiol-benzoate.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 3.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(OC(C5=CC=CC=C5)=O)=C4)[C@@]3([H])CC2

Molecular Formula

C25H28O3

Molecular Weight

376.49

Precautions

H351, H360

References & Citations

[1]Zovko M, et al. Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate. Int J Pharm. 2004 Nov 5;285 (1-2) :35-41.|[2]García-Gómez E, et al. Role of sex steroid hormones in bacterial-host interactions. Biomed Res Int. 2013;2013:928290.|[3]Estradiol benzoate|[4]Xu X, et al. Effects of estradiol benzoate on learning-memory behavior and synaptic structure in ovariectomized mice [J]. Life sciences, 2006, 79 (16) : 1553-1560.|[5]Putz O, et al. Neonatal low-and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland [J]. Biology of reproduction, 2001, 65 (5) : 1496-1505.|[6]He J, et al. Identification of Estradiol Benzoate as an Inhibitor of HBx Using Inducible Stably Transfected HepG2 Cells Expressing HiBiT Tagged HBx [J]. Molecules, 2022, 27 (15) : 5000.|[7]Lu D, et al. Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro [J]. Frontiers in Pharmacology, 2022, 13: 841941.|[8]Rao M V, et al. Effect of estradiol benzoate on reproductive organs and fertility in the male rat [J]. European Journal of Obstetrics & Gynecology and Reproductive Biology, 1983, 15 (3) : 189-198.