Mps1 (TTK) Mouse Monoclonal Antibody [Clone ID: LBI13E9]
Product Specifications
Background
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Synonyms
CT96; ESK; MPH1; MPS1; MPS1L1; PYT
Gene Name
TTK protein kinase
Gene ID
7272
UniProt
P33981
Conjugation
Unconjugated
Related Pathways
Cell cycle, Oocyte meiosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway
Field of Research
Cell cycle, Oocyte meiosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:500
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protein Kinase
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TTK
Overview
TTK mouse monoclonal antibody, clone LBI13E9
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7272
Uniprot URL
https://www.uniprot.org/uniprot/P33981
Curated Selection
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