SIRT-IN-3
SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) [1].
Product Specifications
CAS Number
[1211-19-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt-in-3.html
Purity
99.12
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC=CC=C1NC2=CC=CC=C2
Molecular Formula
C13H12N2O
Molecular Weight
212.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1 (10) :1059-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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