SIRT-IN-3

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) [1].

Product Specifications

CAS Number

[1211-19-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt-in-3.html

Purity

99.12

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N)C1=CC=CC=C1NC2=CC=CC=C2

Molecular Formula

C13H12N2O

Molecular Weight

212.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1 (10) :1059-62.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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