SIRT-IN-3
SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) [1].
Product Specifications
CAS Number
[1211-19-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt-in-3.html
Purity
99.12
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC=CC=C1NC2=CC=CC=C2
Molecular Formula
C13H12N2O
Molecular Weight
212.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1 (10) :1059-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
ZDHHC1, NT (ZDHHC1, C16orf1, ZNF377, Probable palmitoyltransferase ZDHHC1, DHHC domain-containing cysteine-rich protein 1, Zinc finger DHHC domain-containing protein 1, Zinc finger protein 377) (MaxLight 550) discontinued
RPS6KB1 (Ser404) (Ribosomal Protein S6 Kinase beta-1, S6K-beta-1, S6K1, 70kD Ribosomal Protein S6 Kinase 1, P70S6K1, p70-S6K 1, p70 Ribosomal S6 Kinase alpha, p70 S6 Kinase alpha, p70 S6K-alpha, p70 S6KA, p70-S6K, Ribosomal Protein S6 Kinase I, Serine/threonine-protein Kinase 14A, STK14A) (FITC) discontinued
PABPN1, CT (PABPN1, PAB2, PABP2, Polyadenylate-binding protein 2, Nuclear poly (A) -binding protein 1, Poly (A) -binding protein II, Polyadenylate-binding nuclear protein 1) (PE) discontinued