Serotonin N acetyltransferase (AANAT) Mouse Monoclonal Antibody [Clone ID: LBI3B9]
Product Specifications
Background
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms
DSPS; SNAT
Gene Name
Aralkylamine N-acetyltransferase
Gene ID
15
UniProt
Q16613
Conjugation
Unconjugated
Related Pathways
Metabolic pathways, Tryptophan metabolism
Field of Research
Metabolic pathways, Tryptophan metabolism
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
AANAT
Overview
AANAT mouse monoclonal antibody, clone LBI3B9
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=15
Uniprot URL
https://www.uniprot.org/uniprot/Q16613
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