JIP1 (MAPK8IP1) Mouse Monoclonal Antibody [Clone ID: LBI13F10]
Product Specifications
Background
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8) . This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Synonyms
IB1; JIP-1; JIP1; PRKM8IP
Gene Name
Mitogen-activated protein kinase 8 interacting protein 1
Gene ID
9479
UniProt
Q9UQF2
Conjugation
Unconjugated
Related Pathways
MAPK signaling pathway
Field of Research
MAPK signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MAPK8IP1
Overview
MAPK8IP1 mouse monoclonal antibody, clone LBI13F10
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=9479
Uniprot URL
https://www.uniprot.org/uniprot/Q9UQF2
Curated Selection
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