ERCC8 Mouse Monoclonal Antibody [Clone ID: LBI5C9]

Product Specifications

Background

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Overview

ERCC8 mouse monoclonal antibody, clone LBI5C9

Synonyms

CKN1; CSA; UVSS2

Gene Name

ERCC excision repair 8, CSA ubiquitin ligase complex subunit

Gene ID

1161

UniProt

Q13216

Conjugation

Unconjugated

Related Pathways

Nucleotide excision repair, Ubiquitin mediated proteolysis

Field of Research

Nucleotide excision repair, Ubiquitin mediated proteolysis

Concentration

1 mg/ml

Dilution

WB 1:500, IHC 1:150

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Transcription Factors

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.