MAP3K8 Mouse Monoclonal Antibody [Clone ID: LBI2E10]

Product Specifications

Background

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Overview

MAP3K8 mouse monoclonal antibody, clone LBI2E10

Synonyms

AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2

Gene Name

Mitogen-activated protein kinase kinase kinase 8

Gene ID

1326

UniProt

P41279

Conjugation

Unconjugated

Related Pathways

MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Field of Research

MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Concentration

1 mg/ml

Dilution

WB 1:2000

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Protein Kinase

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.