MAP3K8 Mouse Monoclonal Antibody [Clone ID: LBI2E10]
Product Specifications
Background
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Synonyms
AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
Gene Name
Mitogen-activated protein kinase kinase kinase 8
Gene ID
1326
UniProt
P41279
Conjugation
Unconjugated
Related Pathways
MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway
Field of Research
MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protein Kinase
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MAP3K8
Overview
MAP3K8 mouse monoclonal antibody, clone LBI2E10
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1326
Uniprot URL
https://www.uniprot.org/uniprot/P41279
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