CD11b (ITGAM) Mouse Monoclonal Antibody [Clone ID: LBI12C10]
Product Specifications
Background
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Overview
ITGAM mouse monoclonal antibody, clone LBI12C10
Synonyms
CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6
Gene Name
Integrin subunit alpha M
Gene ID
3684
UniProt
P11215
Conjugation
Unconjugated
Related Pathways
Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
Field of Research
Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
Concentration
1 mg/ml
Dilution
WB 1:500, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ITGAM
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3684
Uniprot URL
https://www.uniprot.org/uniprot/P11215
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