ATF1 Mouse Monoclonal Antibody [Clone ID: LBI2B4]
Product Specifications
Background
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3) . Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Synonyms
EWS-ATF1; FUS/ATF-1; TREB36
Gene Name
Activating transcription factor 1
Gene ID
466
UniProt
P18846
Conjugation
Unconjugated
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Transcription Factors
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ATF1
Overview
ATF1 mouse monoclonal antibody, clone LBI2B4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=466
Uniprot URL
https://www.uniprot.org/uniprot/P18846
Curated Selection
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