CD3E Mouse Monoclonal Antibody [Clone ID: UCHT1]
Product Specifications
Background
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Synonyms
IMD18; T3E; TCRE
Gene Name
CD3e molecule
Gene ID
916
UniProt
P07766
Conjugation
Unconjugated
Related Pathways
Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway
Field of Research
Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000, FLOW 1:100
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CD3E
Overview
CD3 mouse monoclonal antibody, clone UCHT1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=916
Uniprot URL
https://www.uniprot.org/uniprot/P07766
Curated Selection
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