CD3E Mouse Monoclonal Antibody [Clone ID: UCHT1]

Product Specifications

Background

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Overview

CD3 mouse monoclonal antibody, clone UCHT1

Synonyms

IMD18; T3E; TCRE

Gene Name

CD3e molecule

Gene ID

916

UniProt

P07766

Conjugation

Unconjugated

Related Pathways

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

Field of Research

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

Concentration

1 mg/ml

Dilution

WB 1:2000, FLOW 1:100

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Transmembrane

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.