Apolipoprotein E (APOE) Mouse Monoclonal Antibody [Clone ID: LBI3F1]

Product Specifications

Background

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]

Overview

APOE mouse monoclonal antibody, clone LBI3F1

Synonyms

AD2; APO-E; LDLCQ5; LPG

Gene Name

Apolipoprotein E

Gene ID

348

UniProt

P02649

Conjugation

Unconjugated

Related Pathways

Alzheimer's disease

Field of Research

Alzheimer's disease

Concentration

1 mg/ml

Dilution

WB 1:2000, IHC 1:150

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.