DCC Mouse Monoclonal Antibody [Clone ID: LBI4A1]
Product Specifications
Background
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Synonyms
CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1
Gene Name
DCC netrin 1 receptor
Gene ID
1630
UniProt
P43146
Conjugation
Unconjugated
Related Pathways
Axon guidance, Colorectal cancer, Pathways in cancer
Field of Research
Axon guidance, Colorectal cancer, Pathways in cancer
Concentration
1 mg/ml
Dilution
WB 1:200
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
DCC
Overview
DCC mouse monoclonal antibody, clone LBI4A1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1630
Uniprot URL
https://www.uniprot.org/uniprot/P43146
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
