PRAK (MAPKAPK5) Mouse Monoclonal Antibody [Clone ID: LBI1B4]
Product Specifications
Background
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov
Synonyms
MAPKAP-K5; MK-5; MK5; PRAK
Gene Name
Mitogen-activated protein kinase-activated protein kinase 5
Gene ID
8550
UniProt
Q8IW41
Conjugation
Unconjugated
Related Pathways
MAPK signaling pathway
Field of Research
MAPK signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protein Kinase
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
MAPKAPK5
Overview
Purified MAPKAPK5 mouse monoclonal antibody, clone LBI1B4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8550
Uniprot URL
https://www.uniprot.org/uniprot/Q8IW41
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