Thyroglobulin (TG) Mouse Monoclonal Antibody [Clone ID: LBI1B2]
Product Specifications
Background
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Synonyms
AITD3; TGN
Gene Name
Thyroglobulin
Gene ID
7038
UniProt
P01266
Conjugation
Unconjugated
Related Pathways
Autoimmune thyroid disease
Field of Research
Autoimmune thyroid disease
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TG
Overview
TG mouse monoclonal antibody, clone LBI1B2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7038
Uniprot URL
https://www.uniprot.org/uniprot/P01266
Curated Selection
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