PTCH1 Mouse Monoclonal Antibody [Clone ID: LBI1H8]
Product Specifications
Background
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008]
Synonyms
BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
Gene Name
Patched 1
Gene ID
5727
UniProt
Q13635
Conjugation
Unconjugated
Related Pathways
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
Field of Research
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
Concentration
1 mg/ml
Dilution
WB 1:200
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PTCH1
Overview
PTCH1 mouse monoclonal antibody, clone LBI1H8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5727
Uniprot URL
https://www.uniprot.org/uniprot/Q13635
Curated Selection
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